自体基质诱导软骨生成（AMIC）是治疗膝关节周围软骨损伤的有效术式吗：文献综述
简介
这篇文献综述评估了自体基质诱导软骨形成（AMIC）修复膝关节软骨及骨软骨缺损的疗效，并与微骨折、基质诱导自体软骨细胞植入（ACI）及骨软骨自体移植等技术进行比较。综述显示，膝关节中期和长期随访中AMIC的功能结局优于微骨折；与基质诱导ACI及自体碎软骨植入相比，AMIC也显示更优的功能结局，而与ACI和骨软骨自体移植的结果相似。其他关节的中期结果良好，但长期…
英文摘要
INTRODUCTION: Autologous matrix-induced chondrogenesis (AMIC) is a single-procedure technique used in the repair of chondral and osteochondral defects, particularly in the knee. Since its introduction, there has been an increasing body of literature exploring its outcomes not only in the knee but in other joints, including the hip, ankle, and shoulder. This review explores present evidence of the AMIC as well as comparing it to other cartilage repair techniques, including microfracture, autologous chondrocyte implantation (ACI), and autograft transplantation. MATERIALS AND METHOD: A literature search was completed with two specific goals: first, to identify present available literature for AMIC and its outcomes; second, to identify literature comparing the outcomes of AMIC to other cartilage repair techniques. RESULTS: This review had identified that AMIC has superior functional outcomes compared to microfracture in the knee in both medium- and long-term follow-up. Within other joints, medium-term outcomes are favorable, but longer-term data are still required. Present literature demonstrates superior functional outcomes in AMIC compared to both matrix induced ACI and autologous minced cartilage implantation. Results from ACI and osteochondral autograft transplant are similar to those achieved with AMIC. CONCLUSION: AMIC represents a viable and effective single-stage technique for the management and osteochondral defects. There is long-term data supporting its superiority to microfracture alone; however, additional evidence comparing outcomes to other repair techniques is still required to establish AMIC as the standard of care for chondral and osteochondral defect management.